The Last Supper painting by Leonardo De Vinci..?

It was also a fresco painting and because of the speed in which it was painted it also didn't keep very well over the years. If my memory serves it was tempera paint, which at the time was mostly pigments water and something glutenous like egg. (Fresco, for those who don't know, is a painting done on wet plaster so that the paint and plaster dry together leaving the painting as part of the wall or ceiling.)